| episode | air date | countdown | title |
| S05E16 | 2019-05-16 | | Journalist Christiane Amanpour | |
| S05E15 | 2019-05-09 | | Bill Nye | |
| S05E14 | 2019-05-09 | | Director Darren Aronofsky | |
| S05E13 | 2019-05-02 | | Author Patricia Cornwell | |
| S05E12 | 2019-05-02 | | Weird Al Yankovic | |
| S05E11 | 2019-04-25 | | Actor James Marsden | |
| S05E10 | 2019-04-25 | | Actor Jeff Goldblum | |
| S05E09 | 2019-04-18 | | Actor Anna Deavere Smith | |
| S05E08 | 2019-04-18 | | Author George R.R. Martin | |
| S05E07 | 2019-04-11 | | News Anchor Dan Rather | |
| S05E06 | 2019-04-11 | | Actor Jack Black | |
| S05E05 | 2019-04-04 | | Vice President Al Gore | |
| S05E04 | 2019-04-04 | | US Space Command | |
| S05E03 | 2018-11-26 | | The Big Bang Theory's Simon Helberg & Bill Pra | |
| S05E02 | 2018-11-19 | | Joe Rogan and the Science of Primitive Man | |
| S05E01 | 2018-11-12 | | Anthony Bourdain | |
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| S04E20 | 2018-03-04 | | Stephen Hawking | |
| S04E19 | 2018-02-25 | | Astronaut Scott Kelly | |
| S04E18 | 2018-02-18 | | Kelly Slater and the Science of Surfing | |
| S04E17 | 2018-02-04 | | Frank Oz and the Science of Puppeteering | |
| S04E16 | 2018-01-28 | | Sam Harris and the Science of Belief | |
| S04E15 | 2018-01-21 | | True Story of Hidden Figures | |
| S04E14 | 2018-01-14 | | Stephen Colbert | |
| S04E13 | 2018-01-07 | | Alan Alda | |
| S04E12 | 2017-12-17 | | Interstellar Space Travel | |
| S04E11 | 2017-12-10 | | Salman Rushdie | |
| S04E10 | 2017-12-03 | | Celestial Navigation | |
| S04E09 | 2017-11-26 | | James Cameron | |
| S04E08 | 2017-11-19 | | Sylvia Earle, Fabien Cousteau & Adrian Grenier | |
| S04E07 | 2017-11-12 | | Katy Perry | |
| S04E06 | 2017-11-05 | | SciFi Meets National Defense | |
| S04E05 | 2017-10-29 | | Kevin Smith | |
| S04E04 | 2017-10-22 | | Katie Couric | |
| S04E03 | 2017-10-15 | | Jane Goodall | |
| S04E02 | 2017-10-08 | | Kareem Abdul-Jabbar | |
| S04E01 | 2017-10-01 | | Lance Armstrong | |
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| |
| S03E20 | 2017-02-06 | | Bill Maher | |
| S03E19 | 2017-01-30 | | Herbie Hancock and Wayne Shorter | |
| S03E18 | 2017-01-23 | | Science of Game of Thrones | |
| S03E17 | 2017-01-16 | | The Science of Weather | |
| S03E16 | 2017-01-09 | | Search for Aliens | |
| S03E15 | 2017-01-02 | | Hope Solo | |
| S03E14 | 2016-12-26 | | US Secretary of Defense Ash Carter | |
| S03E13 | 2016-12-19 | | William Shatner | |
| S03E12 | 2016-12-12 | | Jay Leno | |
| S03E11 | 2016-12-05 | | Terry Crews | |
| S03E10 | 2016-11-28 | | Buzz Aldrin | |
| S03E09 | 2016-11-21 | | Ben Stiller | |
| S03E08 | 2016-11-14 | | The Martian | |
| S03E07 | 2016-11-07 | | Jeremy Irons | |
| S03E06 | 2016-10-24 | | Robert Kirkman and The Walking Dead | |
| S03E05 | 2016-10-17 | | Brian Greene | |
| S03E04 | 2016-10-10 | | Time Travel | |
| S03E03 | 2016-10-03 | | Man on Wire | |
| S03E02 | 2016-09-26 | | Mayim Bialik | |
| S03E01 | 2016-09-19 | | Whoopi Goldberg | |
| |
| S02E10 | 2016-01-03 | | Gina McCarthy | |
| S02E09 | 2015-12-27 | | Brian Cox | |
| S02E08 | 2015-12-20 | | David Crosby | |
| S02E07 | 2015-12-13 | | Mars 1 | |
| S02E06 | 2015-12-06 | | David Byrne | |
| S02E05 | 2015-11-29 | | Susan Sarandon | |
| S02E04 | 2015-11-15 | | Penn & Teller | |
| S02E03 | 2015-11-08 | | Seth MacFarlane | |
| S02E02 | 2015-11-01 | | Larry Wilmore | |
| S02E01 | 2015-10-25 | | Bill Clinton | |
| |
| S01E10 | 2015-06-22 | | Norman Lear | |
| S01E09 | 2015-06-15 | | Charles Bolden/NASA | |
| S01E08 | 2015-06-08 | | Biz Stone | |
| S01E07 | 2015-06-01 | | Chris Hadfield | |
| S01E06 | 2015-05-25 | | Jimmy Carter | |
| S01E05 | 2015-05-18 | | Richard Dawkins | |
| S01E04 | 2015-05-11 | | Arianna Huffington | |
| S01E03 | 2015-05-04 | | Dan Savage | |
| S01E02 | 2015-04-27 | | Christopher Nolan | |
| S01E01 | 2015-04-20 | | George Takei | |
